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H100 PCIe vs RTX 5080

Performance comparison: which is faster?

NVIDIA H100 PCIe (NVIDIA, 2023) and GeForce RTX 5080 (NVIDIA, 2025) are compared here. Compare scores and VRAM, generative AI usability, and CPUs that pair well with each GPU.

Overall performance: H100 PCIe is about 80.6% faster

For generative AI, the higher-VRAM H100 PCIe(80GB) has the advantage. For gaming, prioritize performance score and CPU compatibility; for AI, prioritize VRAM.

NVIDIA / Datacenter
H100 PCIe
65,000 pts
VRAM 80GB · 2023
Best Overall Performance
→ H100 PCIe Details
NVIDIA / RTX 50
RTX 5080
36,000 pts
VRAM 16GB · 2025
→ RTX 5080 Details

Performance Score Comparison

H100 PCIe65,000 pts
RTX 508036,000 pts

Relative performance score (higher is faster). Actual fps varies by resolution, game, and CPU configuration.

Specification Comparison

ItemH100 PCIeRTX 5080
Performance Score65,00036,000
VRAM80GB16GB
ManufacturerNVIDIANVIDIA
SeriesDatacenterRTX 50
Release Year20232025
Compatible CPU ExampleRyzen 9 9950X3DRyzen 9 9950X3D

Generative AI Models Enabled by the VRAM Difference

These generative AI models can run on only one GPU because of the VRAM difference (Stable Diffusion, Flux, LLMs, and others).

Runs Only on H100 PCIe (80GB)

  • FLUX.2 [klein] 9B (FP8)
  • Qwen-Image (FP8)
  • FLUX.2 [dev] (GGUF Q4)
  • FLUX.2 [dev] (GGUF Q5)
  • FLUX.2 [dev] (GGUF Q8)
  • Qwen-Image (GGUF Q8)
  • Llama QLoRA (70B)
  • CogVideoX-5B
  • HunyuanVideo フル
  • Mochi-1 (Genmo)

Runs Only on RTX 5080 (16GB)

— None (all models that run on H100 PCIe also run here)

Which Should You Choose?

If You Want To...Recommended
Prioritize high fps and smooth performance in demanding gamesH100 PCIe
Run larger generative AI and LLM modelsH100 PCIe
Prioritize value and adequate performanceRTX 5080 (the lower model is often sufficient)

Check the Bottleneck with Your CPU →

FAQ

Which is faster, H100 PCIe or RTX 5080?

H100 PCIe is about 80.6% higher by score (H100 PCIe: 65000 points / RTX 5080: 36000 points). Actual fps also varies by resolution, game, and CPU, so price is a reasonable deciding factor when the gap is only a few percent.

How do generative AI support and VRAM differ between H100 PCIe and RTX 5080?

H100 PCIe has 80GB of VRAM, while RTX 5080 has 16GB; H100 PCIe has more. If image generation or a local LLM is even a possibility, the higher-VRAM option provides more room.

Which CPUs pair well with H100 PCIe and RTX 5080?

Using our guideline, Ryzen 9 9950X3D pairs well with H100 PCIe and Ryzen 9 9950X3D with RTX 5080 (CPU:GPU ≈ 0.9:1). If the CPU is too weak, replacing the GPU may not raise fps, so check the combination before buying.

Related Comparisons and Detail Pages

→ H100 PCIe Details / RTX 5080 Details / Compare Another Combination