Performance comparison: which is faster?
AMD Instinct MI100 (AMD, 2020) and Radeon RX 9060 XT (AMD, 2025) are compared here. Compare scores and VRAM, generative AI usability, and CPUs that pair well with each GPU.
Overall performance: Instinct MI100 is about 19% faster
For generative AI, the higher-VRAM Instinct MI100（32GB） has the advantage. For gaming, prioritize performance score and CPU compatibility; for AI, prioritize VRAM.
Relative performance score (higher is faster). Actual fps varies by resolution, game, and CPU configuration.
| Item | Instinct MI100 | RX 9060 XT |
|---|---|---|
| Performance Score | 25,000 | 21,000 |
| VRAM | 32GB | 8GB / 16GB |
| Manufacturer | AMD | AMD |
| Series | Instinct | RX 9000 |
| Release Year | 2020 | 2025 |
| Compatible CPU Example | Core Ultra 7 165H | Ryzen 7 5800 |
These generative AI models can run on only one GPU because of the VRAM difference (Stable Diffusion, Flux, LLMs, and others).
For models sold with multiple VRAM configurations, this comparison uses the lower-capacity configuration.
— None (all models that run on Instinct MI100 also run here)
| If You Want To... | Recommended |
|---|---|
| Prioritize high fps and smooth performance in demanding games | Instinct MI100 |
| Run larger generative AI and LLM models | Instinct MI100 |
| Prioritize value and adequate performance | RX 9060 XT (the lower model is often sufficient) |
Instinct MI100 is about 19% higher by score (Instinct MI100: 25000 points / RX 9060 XT: 21000 points). Actual fps also varies by resolution, game, and CPU, so price is a reasonable deciding factor when the gap is only a few percent.
Instinct MI100 has 32GB of VRAM, while RX 9060 XT has 8GB / 16GB; Instinct MI100 has more. If image generation or a local LLM is even a possibility, the higher-VRAM option provides more room.
Using our guideline, Core Ultra 7 165H pairs well with Instinct MI100 and Ryzen 7 5800 with RX 9060 XT (CPU:GPU ≈ 0.9:1). If the CPU is too weak, replacing the GPU may not raise fps, so check the combination before buying.
